Biografia

O Dr. Deretic é o chefe do departamento do Departamento de Genética Molecular e Microbiologia da Escola de Medicina da Universidade do Novo México. Ele recebeu sua graduação, pós-graduação (Ph.D.) e educação de pós-doutorado em Belgrado, Paris e Chicago. As principais contribuições do Dr. Deretic para a ciência vêm dos estudos de sua equipe sobre o papel da autofagia na infecção e na imunidade. Dr. Deretic é o diretor do Centro de Excelência em Pesquisa Biomédica (CoBRE), financiado pelo NIH, Autophagy, Inflammation and Metabolism (AIM). O centro AIM visa promover a pesquisa em autofagia nacional e internacionalmente, bem como desenvolver um quadro de professores juniores, juntamente com especialistas sênior nesta área, para estudar os mecanismos fundamentais e como a autofagia se cruza com um amplo espectro de doenças humanas e estados de saúde.

Declaração pessoal

Dr. Deretic is an international authority on the role of autophagy in inflammation and immunity. The connections between autophagy and tuberculosis began with Dr. Deretic’s seminal publication on the role of autophagy in control of Mycobacterium tuberculosis (Mtb) published in Cell in 2004. This was followed by sustained development of the filed including Dr. Deretic’s publications in Science 2006, Nature Cell Biology 2010, a series of studies in Immunity, and more recent studies in 2015-2017 published in Molecular Cell, JCB, Developmental Cell, EMBO J, etc. Dr. Deretic has been consistently invited to summarize the new field of autophagy as an innate immunity and anti-inflammatory process as exemplified in the earliest reviews on this topic in 2005 and most recently in Nature Reviews Immunology (2013), JCI (2015) J. Exp. Med. (2015), and JLB (2016). His group reported a broad role of proteins termed TRIMs (82 members in humans) as autophagic regulator-receptors, published in a series articles in Developmental Cell (2014, 2016) J. Cell Biol. (2015), etc. Dr. Deretic’s lab reported on the role of specific SNAREs in controlling how autophagy terminates - in secretion (EMBO J 2017) or degradation (J. Cell Biol, 2018). Most recently, Dr. Deretic and colleagues have uncovered the role of cytosolic lectins, termed galectins, in direct control of mTOR and AMPK, the most upstream regulators of autophagy and master regulators of cellular metabolism (Molecular Cell, 2018). In terms of translational efforts, Dr. Deretic’s group has identified a series of potential therapeutics aimed at autophagy, ready for repurposing (Nature Comm., 2015; and US patent 9572820). Dr. Deretic was 2012 Chair of Gordon Research Conference on Autophagy, and will be the lead organizer/chair of the 2019 Keystone Symposium on Autophagy.

As a Chairman of a basic science department in a medical school and Director of the Autophagy, Inflammation and Metabolism (AIM) center on autophagy, Dr. Deretic has considerable organizational, fiscal, programmatic, mentoring, and networking skills. While his administrative duties are many, his own research has been exceptionally productive and at a cutting edge of international science. Dr. Deretic’s has demonstrated abilities to balance administrative responsibilities with high-end scientific endeavors. Dr. Deretic to this day works experimentally in the laboratory, specializing in high content and quantitative microscopy.

Áreas de especialidade

Autofagia
Tuberculose
HIV
Microbiologia
Imunologia

Conquistas e prêmios

Annual Research Lecturer (UNM) 2022
NIH MERIT award 2018
Basic Science Research Award (UNM HSC) 2015

Undergraduate: Dean’s list 1974-1978
Graduate: October Award, Belgrade, 1978
FEBS fellowship, Paris, France, 1980

Publicações Chave

Jornal artigo
Gutierrez, M, G Master, S, S Singh, S, B Taylor, G, A Colombo, M, I Deretic, Vojo, 2004 Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell, vol. 119, Issue 6, 753-66

Gênero

Masculino

Idiomas

  • Inglês

Cursos ensinados

Cursos de Fase I da UME relacionados com imunologia, microbiologia e doenças infecciosas

Undergraduate medical education

Spring 2022, Microbiology Immunology in UME Phase 1 for MS2025 (medical students graduating in 2025). CBL/TBL (Cannon/Mandell course directors)

Spring 2021, Microbiology Immunology in UME Phase 1 for MS2024 (medical students graduating in 2024). CBL/TBL (Cannon/Mandell course directors)

Spring 2020, Microbiology Immunology in UME Phase 1 for MS2024 (medical students graduating in 2024). CBL/TBL (Cannon/Mandell course directors)

Spring 2019, Microbiology Immunology in UME Phase 1 for MS2025 (medical students graduating in 2025). CBL/TBL (Chackerian/Cannon course directors)

Fall 2018, Infectious disease block, UME Phase 2, PBL tutorials 10 sessions (Iandiorio, course director)

Fall 2017, Infectious disease block, UME Phase 2, PBL tutorials 10 sessions (Iandiorio, course director)

Fall 2016, Infectious disease block, UME Phase 2, PBL tutorials 10 sessions (Iandiorio, course director)

Fall 2014, Immunology block, UME Phase 1, PBL tutorials (Checkarian, course director)

Fall 2013, Immunology block, UME Phase 1, PBL tutorials (Checkarian, course director)


Fall 2012, Immunology block, UME Phase 1, PBL tutorials (Checkarian, course director)

Fall 2011, Immunology block, UME Phase 1, PBL tutorials (Checkarian, course director)

Winter 2010, Infection and Immunity tutorial block, UME Phase 1. PBL tutorials (Mold, course director)

Winter 2009, Infection and Immunity tutorial block, UME Phase 1. 4 lectures, PBL tutorials (Mold, course director)

Winter 2008, Infection and Immunity tutorial block, UME Phase 1. 4 lectures, PBL tutorials (Mold, course director)

Winter 2007, Infection and Immunity tutorial block, UME Phase 1. PBL tutorials, (Mold, course director)

Winter 2006, Infection and Immunity tutorial block, UME Phase 1. PBL tutorials (Mold, course director)

Winter 2005, Infection and Immunity tutorial block, UME Phase 1. PBL tutorials Mold, course director)

Winter 2004, Infection and Immunity tutorial block, UME Phase 1. PBL tutorials Mold, course director)

Winter 2003, Infection and Immunity tutorial block, UME Phase 1. PBL tutorials Mold, course director)

BSGP

2002-2006 BSGP BIOMED 525

2002-2006 BSGP BIOMED 508

Pesquisa e bolsa de estudos

A principal contribuição do Dr. Deretic para a ciência vem do relatório inicial e estudos de acompanhamento sustentados por sua equipe sobre o papel da autofagia na infecção e imunidade, nos quais ele e seu grupo (junto com outros) foram os pioneiros e desenvolveram esta área em um campo florescente de estudo. O pano de fundo histórico para o impacto do trabalho do Dr. Deretic é melhor apreciado pelo entendimento de que a autofagia, antes do trabalho do Dr. Deretic, foi limitada ao seu papel no metabolismo e controle de qualidade citoplasmático (veja o pôster da Nature Reviews de Klionsky & Deretic: http://www.nature.com/nrm/posters/autophagy/index.html). Dr. Deretic’s work on autophagy in immunity coincides with the beginnings of the appreciation of autophagy’s role in human health (1a). Dr. Deretic’s group is one of those that made the discovery that autophagy is a major effector and regulator of immunity (see sections 2,4, and 5 below). A series of invited reviews over past 10 years by Deretic and colleagues attest to the role that Dr. Deretic has played in developing this field and includes the first recognition of the broadly integrated role of autophagy in immunity as well as the most recent summaries of the role of autophagy in immunity and inflammation (1b-d). For other representative primary publications and a breakdown of specific subsets of research contributions in this area see sections 2-5, below.
a. Deretic V, Klionsky DJ. How cells clean house. Sci Am. 2008 May;298(5):74-81. PubMed PMID: 18444328.
b. Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nat Rev Immunol. 2013 Oct;13(10):722-37. PubMed PMID: 24064518.
c. Rubinsztein, DC, Bento, CF, Deretic, V. Therapeutic targeting of autophagy in neurodegenerative and infectious diseases. J Exp Med, 2015, Jun 29;212(7):979-990. PMID: 26101267.
d. Deretic V. Autophagy in leukocytes and other cells: mechanisms, subsystem organization, selectivity, and links to innate immunity. Journal of Leukocyte Biology. 2016; 100(5):969-978. PMID: 27493243.