Biografia
Dr. Rosenberg is a Professor of Neurology with joint appointments in Cell Biology, Neuroscience and Mathematics and Statistics. He joined the faculty of Neurology in 1976, and is currently the Director of the New Mexico Alzheimer?s Disease Research Center (NM ADRC). He is the Founding Director of the UNM Center of Memory and Aging. From 1985 to 2015 he served as Chairman of Neurology, and has trained many neurologists. He graduated from the Albert Einstein College of Medicine and trained there in Neurology. He studied biomedical engineering at the Technion University in Haifa, Israel. His current research is on improving diagnosis in patients with dementia by the use of biomarkers and machine learning. He is an expert in vascular cognitive impairment. He has published over 168 papers and written two books. He has been continuously funded by NIH since 1983, and is now the Principal Investigator on two large NIH grants.
Declaração pessoal
I am a Clinician-Scientist with clinical training in Neurology under Dr. Robert Katzman. Throughout my career I have been involved in research of the pathobiology of neurological disorders. Early studies in animals were on the role of interstitial fluid (ISF) and cerebrospinal fluid (CSF). I showed that ISF moves primarily in the white matter by bulk flow rather than diffusion. This work was important for understanding the white matter injury that are involved in vascular cognitive impairment and dementia (VCID). I spent a sabbatical with Professor Michael Bradbury at King?s College in London, where I learned methods to study blood-brain barrier (BBB) physiology in rodents. My interest in the ISF and extracellular matrix (ECM), lead to the discovery of the role of matrix-metalloproteinases (MMPs) in disruption of the BBB; this work has been extensively quoted and remains a major focus of interest by many investigators. As part of the studies in the ECM, I discovered that bacterial collagenase induced an intracerebral hemorrhage (ICH), leading to one of the most frequently used models of ICH. My current research is on the role of the MMPs in neuroinflammation in dementia. Those studies in rodents have been expanded into humans, and we have developed methods to measure MMPs in CSF. In addition, we adapted to humans the method to measure BBB permeability with contrast-enhanced MRI. White matter changes on MRI are important in both VCID and in Alzheimer?s disease (AD). My early interest in injury to white matter began with a patient that I reported with Binswanger?s disease (BD); this was the first BD patient diagnosed during life by CT and confirmed at autopsy. We showed that MMPs where present in the CSF of patients with VCID and that they were related to the disruption of the BBB. Recently, as part of the MarkVCID consortium, we showed that inflammatory biomarkers in the CSF, such as the MMPs could be used to separate patients with VCID from AD, and to define mixed dementia patients during life. We have a group of MRI experts, biochemists, and statisticians, and as part of VCID, we have worked closely with Charlie DeCarli?s group to identify the optimal biomarkers to use to more precisely classify dementia patients into subgroups. My role in this RFA-driven proposal will be to provide a cohort of patients that have been extensively studied and followed for multiple years with all of the biomarkers selected by MarkVCID, and to work on new methods of analysis.
Áreas de especialidade
comprometimento cognitivo vascular e demência
barreira hematoencefalica
metaloproteinases de matriz
lesão da substância branca
A doença de Alzheimer
Conquistas e prêmios
8/2020-Present Director, New Mexico Exploratory Alzheimer?s Disease Research Center
1/2016-presente Diretor, Centro de Memória e Envelhecimento da Universidade do Novo México
2000-6 meses Cientista Visitante, Departamento de Neurologia, (Neuropatologia), Universidade de Oxford
(Professora Margaret Esiri)
7/1998-presente Professor de Biologia Celular e Fisiologia e Neurociência
7/1996-presente Professor de Matemática e Estatística (Conjunto), UNM
7/1990-presente Professor de Fisiologia (Conjunto), UNM
7/1986-presente Professor de Neurologia, UNM, Faculdade de Medicina
7/1985-12/2015 Presidente, Departamento de Neurologia, UNM, Faculdade de Medicina
7/1988-6/1996 Médico da equipe, Hospital VA, Albuquerque, NM
6/1984-9/1984 Visiting Scientist in the Dept. of Physiology, King's College, London, UK (Professor Michael Bradbury)
7/1982-6/1996 Professor Associado de Matemática e Estatística (Conjunto), UNM
7/1981-6/1990 Professor Associado de Fisiologia (Conjunto) UNM
7/1981-6/1986 Professor Associado de Neurologia, UNM
7/1976-6/1981 Professor Assistente de Neurologia, UNM
7/1976-6/1988 Chefe Adjunto, Serviço de Neurologia, Hospital VA, Albuquerque, NM
7/1973-6/1976 Residente de Neurologia, Albert Einstein College of Medicine
7/1971-6/1973 Programa de Pós-Graduação, Engenharia Biomédica, Technion, Haifa, Israel
7/1971-6/1972 Residente de Neurologia, Technion-Haifa Med School, Haifa, Israel
7/1969-6/1971 Oficial Médico Geral, Base do Exército de Sandia, Albuquerque, NM
7/1968-6/1969 Estagiário, Universidade de Rochester (Genesee Hospital), Rochester, NY
Publicações Chave
Outros
Rosenberg, Gary, 2016 Vascular cognitive impairment: Biomarkers in diagnosis and molecular targets in therapy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 361, 4-5 Journal Article S nchez, K, E Rosenberg, Gary, 2022 Shared Inflammatory Pathology of Stroke and COVID-19. International journal of molecular sciences, vol. 23, Issue 9
Jornal artigo
Caprihan, A, Raja, R, Hillmer, L, J Erhardt, E, B Prestopnik, J, Thompson, J, Adair, John, Knoefel, Janice, Rosenberg, Gary, 2021 Um agrupamento de dupla dicotomia de pacientes com demência de patologia dupla. Circulação cerebral - cognição e comportamento, vol. 2, Emissão
Jornal artigo
Jiang, S, Maphis, N, M Binder, J, Chisholm, D, Weston, L, Duran, W, Peterson, C, Zimmerman, A, Mandell, Michael, Jett, S, D Bigio, E, Geula, C, Mellios renunciou em fevereiro de 2024, Nikolaos, Weick, Jason, Rosenberg, Gary, 2021 O tau proteopático prime e ativa a interleucina-1? através da via do inflamassoma MyD88 e NLRP3-ASC específico para células mieloides. Relatórios de células, vol. 36, Edição 12, 109720
Jornal artigo
Maillard, P, Lu, H, Arfanakis, K, Gold, B, T Bauer, C, E Zachariou, V, Stables, L, Wang DJJ, , Jann, K, Seshadri, S, Duering, M, Hillmer, L, J Rosenberg, Gary, Snoussi, H, Sepehrband, F, 2022 Validação instrumental de água livre, largura de pico de difusividade média esqueletizada e hiperintensidades de substância branca: kits de neuroimagem MarkVCID. Alzheimer e demência (Amsterdã, Holanda), vol. 14, Edição 1, e12261
Gênero
Masculino
Idiomas
- Espanhol
- Hebraico
- Alemão
- Inglês